Potent and Selective PTDSS1 Inhibitors Induce Collateral Lethality in Cancers with PTDSS2 Deletion.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36054550.
- Also identified by DOI 10.1158/0008-5472.CAN-22-1006.
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Abstract
This study identifies a specific dependency on PTDSS1 for phosphatidylserine synthesis following PTDSS2 deletion and introduces novel PTDSS1 inhibitors as a therapeutic option to induce collateral lethality in cancer with PTDSS2 loss.
Medical subject headings
- Neoplasms