A ciliary synapse for "short-circuit" neuromodulation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36055196.
- Also identified by DOI 10.1016/j.cell.2022.08.006.
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Abstract
Nearly all neurons contain a primary cilium, but little is known about how this compartment contributes to neuromodulatory signaling. In a new study, Sheu et al. use cutting-edge electron microscopy and fluorescence imaging techniques to reveal a new type of synapse that enables chemical transmission between serotonergic axons and the primary cilia of hippocampal neurons.
Medical subject headings
- Cilia
- Neurons
- Synapses