SnapShot: Mediator complex structure.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36055203.
- Also identified by DOI 10.1016/j.cell.2022.07.011 and PMC identifier 10686218.
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Abstract
The Mediator complex controls RNA polymerase II transcription genome-wide. In humans, Mediator consists of 26 subunits; furthermore, a four-subunit "Mediator kinase module" can reversibly associate with the complex. Mediator structure is generally conserved from yeast to humans, although the human complex is larger, more structurally disordered, and contains metazoan-specific subunits. To view this SnapShot, open or download the PDF.
Medical subject headings
- Mediator Complex