Small, correlated changes in synaptic connectivity may facilitate rapid motor learning.

Abstract

Animals rapidly adapt their movements to external perturbations, a process paralleled by changes in neural activity in the motor cortex. Experimental studies suggest that these changes originate from altered inputs (H_input) rather than from changes in local connectivity (H_local), as neural covariance is largely preserved during adaptation. Since measuring synaptic changes in vivo remains very challenging, we used a modular recurrent neural network to qualitatively test this interpretation. As expected, H_input resulted in small activity changes and largely preserved covariance. Surprisingly given the presumed dependence of stable covariance on preserved circuit connectivity, H_local led to only slightly larger changes in activity and covariance, still within the range of experimental recordings. This similarity is due to H_local only requiring small, correlated connectivity changes for successful adaptation. Simulations of tasks that impose increasingly larger behavioural changes revealed a growing difference between H_input and H_local, which could be exploited when designing future experiments.