Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC.
basic_science · Level V
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- Record sourced from PubMed, PMID 36067186.
- Also identified by DOI 10.1371/journal.pone.0274219 and PMC identifier 9447916.
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Abstract
Misidentification, cross-contamination and genetic drift of continuous animal cell lines are persistent problems in biomedical research, leading to erroneous results and inconsistent or invalidated studies. The establishment of immortalized hepatic stellate cell line Col-GFP HSC was reported in PLoS One in the year 2013. In the present study a multi loci short tandem repeat signature for this cell line was established that allows for unique cell line authentication.
Medical subject headings
- Hepatic Stellate Cells
- Microsatellite Repeats