Advances toward transformative therapies for tendon diseases.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 36070365.
- Also identified by DOI 10.1126/scitranslmed.abl8814 and PMC identifier 11041812.
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Abstract
Approved therapies for tendon diseases have not yet changed the clinical practice of symptomatic pain treatment and physiotherapy. This review article summarizes advances in the development of novel drugs, biologic products, and biomaterial therapies for tendon diseases with perspectives for translation of integrated therapies. Shifting from targeting symptom relief toward disease modification and prevention of disease progression may open new avenues for therapies. Deep evidence-based clinical, cellular, and molecular characterization of the underlying pathology of tendon diseases, as well as therapeutic delivery optimization and establishment of multidiscipline interorganizational collaboration platforms, may accelerate the discovery and translation of transformative therapies for tendon diseases.
Medical subject headings
- Tendons