MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36070373.
- Also identified by DOI 10.1126/sciadv.abn0047 and PMC identifier 9451160.
- Licence recorded as CC BY-NC.
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Abstract
Gamete fusion is a critical event of mammalian fertilization. A random one-bead one-compound combinatorial peptide library represented synthetic human egg mimics and identified a previously unidentified ligand as Fc receptor-like 3, named MAIA after the mythological goddess intertwined with JUNO. This immunoglobulin super family receptor was expressed on human <i>oolemma</i> and played a major role during sperm-egg adhesion and fusion. MAIA forms a highly stable interaction with the known IZUMO1/JUNO sperm-egg complex, permitting specific gamete fusion. The complexity of the MAIA isotype may offer a cryptic sexual selection mechanism to avoid genetic incompatibility and achieve favorable fitness outcomes.