Uncovering a tripartite landmark in posterior cingulate cortex.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36070384.
- Also identified by DOI 10.1126/sciadv.abn9516 and PMC identifier 9451146.
- Licence recorded as CC BY-NC.
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Abstract
Understanding brain structure-function relationships, and their development and evolution, is central to neuroscience research. Here, we show that morphological differences in posterior cingulate cortex (PCC), a hub of functional brain networks, predict individual differences in macroanatomical, microstructural, and functional features of PCC. Manually labeling 4511 sulci in 572 hemispheres, we found a shallow cortical indentation (termed the inframarginal sulcus; <i>ifrms</i>) within PCC that is absent from neuroanatomical atlases yet colocalized with a focal, functional region of the lateral frontoparietal network implicated in cognitive control. This structural-functional coupling generalized to meta-analyses consisting of hundreds of studies and thousands of participants. Additional morphological analyses showed that unique properties of the <i>ifrms</i> differ across the life span and between hominoid species. These findings support a classic theory that shallow, tertiary sulci serve as landmarks in association cortices. They also beg the question: How many other cortical indentations have we missed?