Walking the high wire: How neurons maintain stability in the crossline of neurodegeneration.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 36070677.
- Also identified by DOI 10.1016/j.cmet.2022.08.013.
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Abstract
In this issue of Cell Metabolism, Traxler et al. report a metabolic switch in neurons that hinges on the critical balance of pyruvate kinase M (PKM) isoform ratios. Using directly induced neurons (iNs) derived from patients with Alzheimer's disease (AD), the work delineates the impact of an AD-specific switch from PKM1 to PKM2 onto neuronal resilience against neurodegeneration.
Medical subject headings
- Neurons
- Pyruvate Kinase