A brown fat-selective mechanism of mitochondrial calcium import?
other · Level V
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- Record sourced from PubMed, PMID 36070679.
- Also identified by DOI 10.1016/j.cmet.2022.08.011.
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Abstract
In this issue of Cell Metabolism, Xue et al. propose that the mitochondrial calcium uniporter (MCU) binds uncoupling protein 1 (UCP1) via the MCU regulator (EMRE) to form a protein complex that the authors term the "thermoporter." Through gain- and loss-of-function experiments, the authors infer that the thermoporter promotes calcium influx into the mitochondrial matrix to enhance NADH production, which supports thermogenesis in brown adipose tissue (BAT).
Medical subject headings
- Adipose Tissue, Brown
- Calcium