Bidirectional lysosome transport: a balancing act between ARL8 effectors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36071047.
- Also identified by DOI 10.1038/s41467-022-32965-y and PMC identifier 9452499.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Most organelles move bidirectionally on microtubule tracks, yet how this opposing movement is regulated by kinesin and dynein remains unclear. Recent work found that ARL8, a known anterograde adaptor linking the lysosome to kinesin, also links lysosomes to the retrograde motor dynein, providing key insight into bidirectional organelle movement in cells.
Medical subject headings
- ADP-Ribosylation Factors
- Lysosomes