Talc Inhalation in Rats and Humans: A Review and Appraisal of Available Evidence.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 36094093.
- Also identified by DOI 10.1097/JOM.0000000000002702 and PMC identifier 9897267.
- Licence recorded as CC BY-NC-ND.
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Abstract
Current information on the health effects and toxicology of talc suggests that this may lead to a specific target organ toxicity arising from repeated exposure (STOT-RE) classification. To provide an assessment of the currently available inhalation toxicity data on talc and to put these data in the perspective of other poorly soluble low-toxicity particles. A database of 177 articles was gathered from different sources. Relevant animal data sets were subjected to a quality review, and epidemiological studies on talc and lung effects published since 2016 were reviewed. Of nine original inhalation studies reviewed, only one study using rats and mice met the criteria that are needed to include for a reliable evaluation for STOT-RE. Together with the pulmonary effects observed in exposed talc miners, a STOT-RE 1 classification is warranted.
Medical subject headings
- Talc
- Inhalation Exposure