Alpha-Synuclein RT-QuIC in Idiopathic Normal Pressure Hydrocephalus.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 36094107.
- Also identified by DOI 10.1002/ana.26505.
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Abstract
This study quantified the occurrence of an underlying synucleinopathy in 50 patients with idiopathic normal pressure hydrocephalus by means of real-time quaking-induced conversion, a highly sensitive and specific technique capable of detecting and amplifying misfolded aggregated forms of α-synuclein in the cerebrospinal fluid. Seven patients were positive and they did not differ from negative cases, except for a more frequent L-dopa responsiveness and gait characterized by a wider base. The two groups did not differ in terms of response rate to tap test or shunt surgery, although step length and gait velocity improved by a lesser extent in positive cases. ANN NEUROL 2022;92:985-991.
Medical subject headings
- Hydrocephalus, Normal Pressure
- Synucleinopathies