Quantitative Spatial Profiling of TILs as the Next Step beyond PD-L1 Testing for Immune Checkpoint Blockade.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 36103258.
- Also identified by DOI 10.1158/1078-0432.CCR-22-2277 and PMC identifier 9669208.
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Abstract
Analysis of tumor-infiltrating lymphocyte (TIL) functional states, particularly tumor-reactive PD-1T TILs, within specific spatial context, can serve as a biologically informed predictive marker of immunotherapy that may be superior to standard clinical biomarkers. High-plex quantitative immune cell phenotyping within their spatial context has tremendous potential in immuno-oncology. See related article by Hummelink et al., p. 4893.
Medical subject headings
- Carcinoma, Non-Small-Cell Lung
- Lung Neoplasms