Slow Waning of Antibodies Following BNT162b2 as a Third Dose in Adults Who Had Previously Received 2 Doses of Inactivated Vaccine.

Cowling, Benjamin J; Cheng, Samuel M S; Martín-Sánchez, Mario; Au, Niki Y M; Chan, Karl C K; Li, John K C; Fung, Lison W C; Luk, Leo L H et al. · J Infect Dis · 2023

case_series · Level IV

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Abstract

We administered BNT162b2 as a third dose to 314 adults aged ≥30 years who had previously received 2 doses of inactivated vaccine. We collected blood samples before the third dose and again after 1 month and 6 months, and found robust antibody responses to the ancestral strain at 6 months after receipt of BNT162b2. Antibody responses to Omicron BA.2 by live virus neutralization were weaker after the third dose and had declined to a low level by 6 months.

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