Epstein-Barr virus: Biology and clinical disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 36113467.
- Also identified by DOI 10.1016/j.cell.2022.08.026 and PMC identifier 9529843.
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Abstract
Epstein-Barr virus (EBV) is a ubiquitous, oncogenic virus that is associated with a number of different human malignancies as well as autoimmune disorders. The expression of EBV viral proteins and non-coding RNAs contribute to EBV-mediated disease pathologies. The virus establishes life-long latency in the human host and is adept at evading host innate and adaptive immune responses. In this review, we discuss the life cycle of EBV, the various functions of EBV-encoded proteins and RNAs, the ability of the virus to activate and evade immune responses, as well as the neoplastic and autoimmune diseases that are associated with EBV infection in the human population.
Medical subject headings
- Epstein-Barr Virus Infections
- Herpesvirus 4, Human