Histologic Activity in an Endoscopically Normal-Appearing Pouch Predicts Future Risk of Pouchitis in Patients With Ulcerative Colitis.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 36114766.
- Also identified by DOI 10.14309/ajg.0000000000002013 and PMC identifier 9822853.
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Abstract
The impact of histologic inflammation on subsequent risk of acute pouchitis in patients with ulcerative colitis (UC) has not been robustly examined. We examined the association between histologic inflammation in endoscopically normal-appearing ileal pouches in patients with UC with subsequent risk of antibiotic-responsive acute pouchitis. Among 163 study patients, 53% had histologic inflammation in an endoscopically normal-appearing ileal pouch. Histologic inflammation in the pouch was associated with an increased risk of pouchitis (24.1% vs 6.8%, adjusted odds ratio 4.41, 95% confidence interval 1.48-13.20). Histologic inflammation in an endoscopically normal pouch was associated with an increased risk of acute pouchitis.
Medical subject headings
- Colitis, Ulcerative
- Pouchitis
- Colonic Pouches
- Proctocolectomy, Restorative