Proliferative verrucus leukoplakia: A case series.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 36119284.
- Also identified by DOI 10.4103/jfmpc.jfmpc_646_21 and PMC identifier 9480668.
- Licence recorded as CC BY-NC-SA.
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Abstract
Oral proliferative verrucous leukoplakia (OPVL) is a rare form of oral leukoplakia first reported in 1985. It is a longterm progressive condition, which develops initially as a white plaque of hyperkeratosis that eventually becomes a multifocal disease with confluent, exophytic, and proliferative features. It has no racial preference with female predilection, associated with various factors including human papillomavirus (HPV) association, genetic susceptibility, and long-standing low-grade traumatic factors. The malignancy transformation rate varies from 0.13 to 17.5% with frequent recurrences. Here, we have reported two cases of PVL seen over the tongue and palate. It is confirmed by clinical and histopathological features and treated with Vitamin A and its supplements and a long-term follow-up showed no recurrence, and hence, Vitamin A has proven as a potent treatment option of PVL by its antioxidant and epithelialization property.