This is GlycoQL.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36124803.
- Also identified by DOI 10.1093/bioinformatics/btac500.
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Abstract
We have previously designed and implemented a tree-based ontology to represent glycan structures with the aim of searching these structures with a glyco-driven syntax. This resulted in creating the GlySTreeM knowledge-base as a linchpin of the structural matching procedure and we now introduce a query language, called GlycoQL, for the actual implementation of a glycan structure search. The methodology is described and illustrated with a use-case focused on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spike protein glycosylation. We show how to enhance site annotation with federated queries involving UniProt and GlyConnect, our glycoprotein database. https://glyconnect.expasy.org/glycoql/.
Medical subject headings
- COVID-19
- SARS-CoV-2