Reverse transcriptase meets DNA, again: Possible roles for transposable elements in host DNA repair.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36179663.
- Also identified by DOI 10.1016/j.cell.2022.09.012.
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Abstract
Retrotransposons are selfish genetic elements that encode an enzyme, reverse transcriptase (RT), which converts the element-encoded RNA into DNA prior to or during genomic integration. New studies provide compelling evidence that a bacterial group II intron-like RT has adapted enzymatic activities associated with RTs to function in host DNA repair.
Medical subject headings
- RNA-Directed DNA Polymerase
- Retroelements