Learning RNA structure prediction from crowd-designed RNAs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36192465.
- Also identified by DOI 10.1038/s41592-022-01607-y and PMC identifier 9528868.
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Abstract
RNA molecules designed by citizen scientists and probed in high-throughput experiments highlighted discrepancies among RNA folding algorithms in their ability to predict RNA structure ensembles. These datasets were used to train a new algorithm that demonstrated improved performance in a collection of independent datasets, including viral genomic RNAs and mRNAs probed in cells.
Medical subject headings
- Algorithms
- RNA