Dietary sugar lowers immunity and microbiota that protect against metabolic disease.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 36198287.
- Also identified by DOI 10.1016/j.cmet.2022.09.006.
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Abstract
Diet influences intestinal microbiota, inflammation, and metabolism. Kawano et al. show that dietary sugar engaged upper gut innate lymphoid cells to replace segmented filamentous bacteria with a pathobiont. Added sugar worsened early metabolic disease by lowering protective Th17 immunity, thereby promoting intestinal lipid absorption and obesity in high-fat-diet-fed mice.
Medical subject headings
- Metabolic Diseases
- Microbiota