Cap CASP, not SCAP, to fight steatohepatitis.
Level V
Where this comes from
- Record sourced from PubMed, PMID 36198289.
- Also identified by DOI 10.1016/j.cmet.2022.09.014.
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Abstract
Hepatic lipid synthesis through SREBP has recently been found to be regulated not only through the canonical pathway involving SCAP in response to sterol deficiency, but also through the PIDDosome and CASP2. In this issue, Kim et al. identify a novel interaction between these two pathways in diet-induced non-alcoholic steatohepatitis.
Medical subject headings
- Fatty Liver
- Intracellular Signaling Peptides and Proteins