Turning the tide: From fibrosis to regeneration following anti-fibrogenic cell vaccination.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 36206727.
- Also identified by DOI 10.1016/j.stem.2022.09.007.
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Abstract
Fibrosis, the pathological end stage of chronic inflammatory diseases, results from extracellular matrix deposition by fibrogenic fibroblasts. In this issue of Cell Stem Cell, Sobecki et al. (2022) develop a novel vaccination-based immunotherapy against fibrogenic progenitor-restricted antigens, leading to the regression of fibrosis in concert with liver and lung regeneration.
Medical subject headings
- Extracellular Matrix
- Liver