Functional genomics of complex cancer genomes.
Level V
Where this comes from
- Record sourced from PubMed, PMID 36207330.
- Also identified by DOI 10.1038/s41467-022-33717-8 and PMC identifier 9547052.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Cancer functional genomics is the study of how genetic, epigenetic, and transcriptional alterations affect cancer phenotypes, such as growth and therapeutic response. Here, we comment on how, taking advantage of next generation sequencing, functional genomics, often combined with systems biology approaches, has revealed novel cancer vulnerabilities beyond the original paradigm of one gene-one phenotype.
Medical subject headings
- Genomics
- Neoplasms