Child Neurology: Familial Hemophagocytic Lymphohistiocytosis Underlying Isolated CNS Inflammation.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 36216522.
- Also identified by DOI 10.1212/WNL.0000000000201124.
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Abstract
Encephalitis and encephalopathy in children represent a diagnostic challenge. We describe a patient with relapsing encephalitis in whom the differential diagnosis included acute disseminated encephalomyelitis, human herpesvirus 6 encephalitis, and hemophagocytic lymphohistiocytosis (HLH). Because of its rarity, HLH is often overlooked as a differential diagnosis in encephalitis, especially in the isolated CNS forms. As this case illustrates, inborn errors of immunity can underlie isolated encephalitis and should be included in the differential diagnosis of these presentations.
Medical subject headings
- Brain Diseases
- Encephalitis
- Lymphohistiocytosis, Hemophagocytic
- Neurology