Premalignant Conditions of Bone.

Eckhoff, Michael D; Wells, Matthew E; Padilla, Osvaldo; Polfer, Elizabeth M; Castagno, Christopher J; Thabet, Ahmed M; Elzamly, Shaimaa; Wilson, Harry L et al. · J Am Acad Orthop Surg Glob Res Rev · 2022

review · Level V

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Abstract

Development of malignancy is a multifactorial process, and there are multitude of conditions of bone that may predispose patients to malignancy. Etiologies of malignancy include benign osseous conditions, genetic predisposition, and extrinsic conditions. New-onset pain or growth in a previously stable lesion is that should concern for malignant change and should prompt a diagnostic workup for malignancy.

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