[2]-Ladderanes as isosteres for meta-substituted aromatic rings and rigidified cyclohexanes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36229621.
- Also identified by DOI 10.1038/s41467-022-33827-3 and PMC identifier 9561113.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Aromatic ring isosteres and rigidified saturated hydrocarbons are important motifs to enable drug discovery. Herein we disclose [2]-ladderanes as a class of meta-substituted aromatic ring isosteres and rigidified cyclohexanes. A straightforward synthesis of the building blocks is presented along with representative derivatization. Preliminary studies reveal that the [2]-ladderanes offer similar metabolic and physicochemical properties thus establishing this class of molecules as interesting motifs.
Medical subject headings
- Cyclohexanes