DUB'ling down uncovers an X-linked vulnerability in Alzheimer's disease.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 36240738.
- Also identified by DOI 10.1016/j.cell.2022.09.029 and PMC identifier 10029816.
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Abstract
Although women are at higher risk for Alzheimer's disease and other tauopathies, the underlying mechanisms are unclear. In this issue of Cell, Yan et al. show that aberrantly high activity of X-linked USP11 deubiquitinase in women impairs clearance of tau, the principal component of neurofibrillary tangles in Alzheimer's disease.
Medical subject headings
- Alzheimer Disease
- Tauopathies