The JAK-STAT pathway at 30: Much learned, much more to do.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 36240739.
- Also identified by DOI 10.1016/j.cell.2022.09.023 and PMC identifier 9815833.
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Abstract
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway arose from investigations of how cells respond to interferons (IFNs), revealing a paradigm in cell signaling conserved from slime molds to mammals. These discoveries revealed mechanisms underlying rapid gene expression mediated by a wide variety of extracellular polypeptides including cytokines, interleukins, and related factors. This knowledge has provided numerous insights into human disease, from immune deficiencies to cancer, and was rapidly translated to new drugs for autoimmune, allergic, and infectious diseases, including COVID-19. Despite these advances, major challenges and opportunities remain.
Medical subject headings
- COVID-19
- Janus Kinases