Hepatitis B Virus (HBV) Replication During Tenofovir Therapy Is Frequent in Human Immunodeficiency Virus/HBV Coinfection.

Hofmann, Eveline; Surial, Bernard; Boillat-Blanco, Noémie; Günthard, Huldrych F; Stöckle, Marcel; Bernasconi, Enos; Schmid, Patrick; Calmy, Alexandra et al. · Clin Infect Dis · 2023

prospective_cohort · Level II

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Abstract

In the Swiss HIV Cohort Study, 61 of 222 (27%) HIV-suppressed persons with chronic hepatitis B virus (HBV) infection had HBV replication after 2 years on tenofovir, of whom 77% were suppressed thereafter. Self-reported adherence to therapy and HBV viral load at tenofovir initiation were predictors of persistent replication.

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