Prostaglandin production selectively in brain endothelial cells is both necessary and sufficient for eliciting fever.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36252026.
- Also identified by DOI 10.1073/pnas.2122562119 and PMC identifier 9618080.
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Abstract
Fever is known to be elicited by prostaglandin E<sub>2</sub> acting on the brain, but its origin has remained disputed. We show in mice that selective deletion of prostaglandin synthesis in brain endothelial cells, but not in neural cells or myeloid cells, abolished fever induced by intravenous administration of lipopolysaccharide and that selective rescue of prostaglandin synthesis in brain endothelial cells reinstated fever. These data demonstrate that prostaglandin production in brain endothelial cells is both necessary and sufficient for eliciting fever.
Medical subject headings
- Dinoprostone
- Endothelial Cells
- Fever