Urine Tenofovir Levels Strongly Correlate With Virologic Suppression in Patients With Human Immunodeficiency Virus on Tenofovir Alafenamide-Based Antiretroviral Therapy.

Johnson, Kelly A; Okochi, Hideaki; Arreguin, Mireya; Watabe, Joseph; Glidden, David V; Chattopadhyay, Anindita; Imbert, Elizabeth; Hickey, Matthew D et al. · Clin Infect Dis · 2023

cross_sectional · Level IV

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Abstract

We found that urine tenofovir (TFV) levels >1500 ng/mL strongly predict virologic suppression among people with human immunodeficiency virus taking tenofovir alafenamide (odds ratio, 5.66; 95% confidence interval, 1.59-20.14; P = .007). This suggests an existing point-of-care assay developed for tenofovir disoproxil fumarate will support adherence monitoring for patients on all TFV-based antiretrovirals.

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