203 Pb-VMT-α-NET Scintigraphy of a Patient With Neuroendocrine Tumor.

Müller, Dirk; Herrmann, Hendrik; Schultz, Michael K; Solbach, Christoph; Ettrich, Thomas; Prasad, Vikas · Clin Nucl Med · 2023

case_report · Level V

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Abstract

In an end-stage midgut neuroendocrine tumor patient with carcinoid heart disease, right ventricular dysfunction, mildly reduced renal function, and refractory to 6 cycles of 177 Lu-HA-DOTATATE therapy, planar, and 22 hours SPECT/CT images were acquired after injection of 224 MBq of 203 Pb-VMT-α-NET to assess the feasibility of performing 212 Pb-VMT-α-NET therapy. A comparison of the 1.5 and 22 hours SPECT/CT images with 68 Ga-HA-DOTATATE PET/CT showed high uptake of 203 Pb-VMT-α-NET in liver metastases matching with the results of the PET/CT investigation.

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