The Macrophage-Associated LncRNA MALR Facilitates ILF3 Liquid-Liquid Phase Separation to Promote HIF1α Signaling in Esophageal Cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36264156.
- Also identified by DOI 10.1158/0008-5472.CAN-22-1922.
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Abstract
Secretion of TNFα by tumor-associated macrophages stimulates cancer cells to upregulate lncRNA MALR, which induces ILF3 liquid-liquid phase separation and activation of HIF1α signaling to promote cancer progression.
Medical subject headings
- Esophageal Squamous Cell Carcinoma
- RNA, Long Noncoding
- Esophageal Neoplasms