Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36266362.
- Also identified by DOI 10.1038/s41536-022-00259-y and PMC identifier 9585072.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNT<sub>MyoD</sub>) to injured tissue in vivo. TNT<sub>MyoD</sub> was performed on skin and successfully induced expression of myogenic factors. TNT<sub>MyoD</sub> was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNT<sub>MyoD</sub> is promising as VML intervention.