Chloride-sensitive signaling turns the potassium switch on.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36272750.
- Also identified by DOI 10.1016/j.kint.2022.08.023.
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Abstract
The potassium switch refers to plasma potassium regulation of the sodium-chloride cotransporter (NCC), which controls distal sodium delivery and therefore potassium secretion. Low extracellular potassium activates NCC by relieving chloride inhibition of With-No-Lysine 4 (WNK4). A new mouse model carrying a chloride-insensitive WNK4 mutant still shows NCC activation on low potassium diet. These effects are mediated by WNK4 activation and kelch-like 3 (KLHL3) inhibition and reveal additional chloride-sensitive pathways for NCC activation.
Medical subject headings
- Potassium
- Chlorides