Endothelium and endothelin: regulators of arterial stiffness and fibrinolysis in ANCA-associated vasculitis.
editorial · Level V
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- Record sourced from PubMed, PMID 36272753.
- Also identified by DOI 10.1016/j.kint.2022.08.029.
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Abstract
In this issue, Farrah et al. report clinical investigations in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). They demonstrate that endothelium-dependent vasodilatation, fibrinolytic capacity, and monocyte-dependent endothelin-1 clearance are reduced in patients with AAV, whereas circulating levels of endothelin-1 and vascular stiffness are increased. Acute infusion of an endothelin ET<sub>A</sub> receptor antagonist reduced vasoconstriction and arterial stiffness. This Commentary discusses biological insights and clinical implications of this study.
Medical subject headings
- Vascular Stiffness
- Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis