Microglia are SYK of Aβ and cell debris.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36306731.
- Also identified by DOI 10.1016/j.cell.2022.09.043.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
During neurodegenerative disease, resident CNS macrophages termed "microglia" assume a neuroprotective role and engulf toxic protein aggregates and cell debris. In this issue of Cell, two groups independently show how spleen tyrosine kinase (SYK) acts downstream of microglial surface receptors to propagate this neuroprotective program in vivo.
Medical subject headings
- Microglia
- Neurodegenerative Diseases