Adding data to gut feelings.

Marsland, Benjamin J; Harris, Nicola L · Cell · 2022

editorial · Level V

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Abstract

Pain-sensing neurons detect environmental insults and tissue injury, driving avoidance behavior and the local release of neuropeptides. Two related papers in this issue of Cell report that gut-innervating pain neurons sense bacterial presence to both shape the constituents of the gut microbiome and protect against excessive inflammation.

Medical subject headings