Kir2.1 channel: Macrophage plasticity in tumor microenvironment.
other · Level V
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- Record sourced from PubMed, PMID 36323230.
- Also identified by DOI 10.1016/j.cmet.2022.10.009.
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Abstract
Diverse ion channels have dysregulated functional expression in the tumor microenvironment (TME). In this issue of Cell Metabolism, Chen et al. reveal that high intratumoral K<sup>+</sup> ions restrict the plasticity of tumor-associated macrophages (TAMs). Inhibition of the Kir2.1 potassium channel induced metabolic reprogramming and repolarization of pro-tumor M2-TAMs to tumoricidal M1-like states.
Medical subject headings
- Tumor Microenvironment
- Neoplasms