An emerging direction in glucagon-based therapy.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 36323231.
- Also identified by DOI 10.1016/j.cmet.2022.10.004.
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Abstract
Glucagon receptor (GCGR) is an essential regulator of hepatic metabolism. In this issue of Cell Metabolism, Sekar et al. report that the endosomal protein Vps37a uncouples hepatic glucose production from lipid metabolism by altering the intracellular localization of GCGR, thereby providing a new potential therapeutic direction for type 2 diabetes.
Medical subject headings
- Glucagon
- Diabetes Mellitus, Type 2