Glioblastoma stem cell HISTArionics.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36332566.
- Also identified by DOI 10.1016/j.stem.2022.10.004.
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Abstract
Glioblastomas are lethal malignancies that possess a rapidly evolving microenvironment containing necrotic/hypoxic areas, aberrant microvasculature, and glioblastoma stem cells (GSCs) that promote tumor growth, recurrence, and treatment resistance. Chen et al. find that GSCs drive integrated epigenetic and metabolic control of angiogenesis via histamine and propose antihistamines as potential therapies.
Medical subject headings
- Glioblastoma
- Brain Neoplasms