A three-component multi-b-value diffusion-weighted imaging might be a useful biomarker for detecting microstructural features in gliomas with differences in malignancy and IDH-1 mutation status.

Abstract

The purpose of the study was to explore the performance of a three-component diffusion model in evaluating the degree of malignancy and isocitrate dehydrogenase 1 (IDH-1) gene type of gliomas. Overall, 60 patients with gliomas were enrolled. The intermediate and perfusion-related diffusion coefficients (D_int and D_p) and fractions of strictly limited, intermediate, and perfusion-related diffusion (F_very-slow, F_int, and F_p) were obtained with a three-component diffusion model. Parameters were also obtained from a diffusion kurtosis model and mono- and biexponential models. All parameters were compared between different tumor grades and IDH-1 gene types. Diagnostic performance and logistic regression analyses were performed. High-grade gliomas (HGGs) had significantly higher F_int, F_very-slow, and D_p values but significantly lower F_p and D_int values than low-grade gliomas (LGGs), and F_int and F_p differed significantly among grade II, III, and IV gliomas (p < 0.05 for all). F_int achieved the highest AUC of 0.872 in differentiating between LGGs and HGGs. Logistic regression analysis revealed that in each model, F_int, diffusion coefficient (D), apparent diffusion coefficient (ADC), mean diffusivity (MD), and mean kurtosis (MK) were associated with glioma grading. After multiple regression analysis, F_int remained the only differentiator. Additionally, F_int and F_p showed significant differences between IDH-1 mutated and IDH-1 wild-type gliomas (p = 0.007 and 0.01, respectively). The three-component DWI model served as a useful biomarker for detecting microstructural features in gliomas with different grades and IDH-1 mutation statuses. • The three-component model enables the estimation of an intermediate diffusion component. • The three-component model performed better than the other models in glioma grading and genotyping. • F_int was useful in evaluating the grade and genotype of gliomas.