Advancing beyond the twists and turns of T cell exhaustion in cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 36350991.
- Also identified by DOI 10.1126/scitranslmed.abo4997 and PMC identifier 10000016.
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Abstract
Chronic antigen stimulation leads to T cell exhaustion. Nutrient restrictions and other suppressive factors in the tumor microenvironment further exacerbate T cell dysfunction. Better understanding of heterogeneity and dynamics of exhausted CD8 T cells will guide novel therapies that modulate T cell differentiation to achieve more effective antitumor responses.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Neoplasms