The Association Between Prebooster Vaccination Antibody Levels and the Risk of Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

Barda, Noam; Canetti, Michal; Gilboa, Mayan; Asraf, Keren; Indenboim, Victoria; Weiss-Ottolenghi, Yael; Amit, Sharon; Zubli, Daniel et al. · Clin Infect Dis · 2023

prospective_cohort · Level II

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Abstract

The correlation between anti-severe acute respiratory syndrome coronavirus 2 antibody levels and infection was reported. Here, we estimated the role of pre-fourth dose levels using data from 1098 healthcare workers. The risk of infection was reduced by 46% (95% confidence interval, 29%-59%) for each 10-fold increase in prebooster levels. Prebooster antibody levels could be used to optimally time boosters.

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