Visualizing ligand bias at the Mu-opioid receptor.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 36368303.
- Also identified by DOI 10.1016/j.cell.2022.10.013.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Different opioid ligands can result in biased μ-opioid signaling, differentially activating signal cascades which produce analgesia, tolerance, or adverse effects. In this issue of Cell, Xu et al. used cryo-EM and computational simulations to understand how different μ-opioid receptor selective-ligands interact with key residues to produce downstream signaling.
Medical subject headings
- Analgesics, Opioid
- Pain