STINGing the immune system: lessons learned through a model of G34-mutant pediatric high-grade glioma.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 36377657.
- Also identified by DOI 10.1172/JCI164420 and PMC identifier 9663148.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Pediatric high-grade gliomas (pHGGs) are aggressive diseases with poor outcomes. The diverse molecular heterogeneity in these rare tumors and inadequate tumor models have limited the development of effective therapies. In this issue of the JCI, Haase et al. produced a genetically engineered mouse model of H3.3-G34R-mutant pHGG to help identify vulnerabilities in DNA repair pathways. The authors designed a therapy that combined radiation with DNA damage response inhibitors to induce an adaptive immune response and extend survival. These findings suggest that combinations of small-molecule therapies with immunotherapies could drive a more durable response and improve mortality for patients with pHGG.
Medical subject headings
- Brain Neoplasms
- Glioma