Cardiovascular Outcomes After Tixagevimab and Cilgavimab use for Pre-Exposure Prophylaxis Against Coronavirus Disease 2019: A Population-Based Propensity-matched Cohort Study.

Birabaharan, Morgan; Hill, Eddie; Begur, Maedha; Kaelber, David C; Martin, Thomas C S; Mehta, Sanjay R · Clin Infect Dis · 2023

retrospective_cohort · Level III

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Abstract

Tixagevimab and cilgavimab treatment was associated with higher rates of cardiovascular events in a post hoc analysis of a phase 3 trial. In this large population-based propensity-matched study, we found no increased risk of cardiovascular events up to 90 days after tixagevimab and cilgavimab administration, including in patients with pre-existing cardiovascular disease.

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