Monocytes: A Promising New TRAIL in Ovarian Cancer Cell Therapy.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 36383129.
- Also identified by DOI 10.1158/1078-0432.CCR-22-2877.
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Abstract
Adoptive cell transfer of IFN-activated monocytes administered intraperitoneally to patients with platinum-resistant ovarian cancer demonstrated antitumor effects and acceptable tolerability. The exposure of monocytes to IFNα and IFNγ upregulated TRAIL, which triggered caspase 8 and direct cell-to-cell contact-dependent apoptosis of ovarian cancer cells. See related article by Green et al., p. 349.
Medical subject headings
- Monocytes
- Ovarian Neoplasms